Bridging Structural Biology & Cell Biology: Designing Fusion Protein Therapeutics Using 3D Cell-Surface Models
- Constructing three-dimensional structural models of the red blood cell surface to contextualize drug–target interactions beyond single protein structures
- Using structural insight to design engineered fusion proteins that achieve tissue targeting while minimizing unintended crosslinking and side effects
- Demonstrating how rational protein design, leveraging published cryo-EM structural data, can replace large discovery platforms, enabling small teams to develop novel biologics efficiently
- Leveraging published cryo-EM structural data and integrative modelling to connect molecular structures with cell-level therapeutic mechanisms