Reframing Structure-Based Drug Design for Induced Proximity Modalities in Multi-Protein Systems
- Designing constructs, stabilization strategies, and binding partners to bias multi-protein assemblies toward structurally tractable states without distorting biology
- Determining when cryo-EM, crystallography, HDX-MS, or native MS are best suited to resolve induced proximity complexes with partial or dynamic occupancy
- Evaluating where co-folding, docking and modelling of multi-protein assemblies have aligned with function
- Strategies for managing scale and throughput when programs demand repeated structural readouts