Stabilizing Functional GPCR States Using ConfoBodies to Enable Structure-Guided Discovery
- Case study demonstrating how structural insights led to De Novo Nanobody discovery
- Addressing the challenge of isolating GPCRs from the membrane while preserving functional folding and conformational integrity for structural analysis
- Applying complementary structural and biophysical techniques to distinguish functionally relevant GPCR States from preparation-induced or non-productive conformations