Targeting the SK2 Potassium Channel: Enabling Structure-Based Drug Discovery of Membrane Proteins Through an Integrated Cryo EM Pipeline
- Integrating rapid construct screening approaches to optimize design, expression, and protein yield
- Developing robust biophysical assays to validate screening hits and prioritize targets for structural studies
- Implementing end-to-end cryo-EM workflows including grid preparation and screening, data processing, model building, and structure interpretation