Huixian Wu
Head of Structural Biology Pfizer
Dr. Huixian Wu received her PhD in Structural Biology and Chemistry from the Scripps Research Institute (La Jolla, CA) in the laboratory of Prof. Raymond C. Stevens. While in Stevens lab, Dr. Wu focused on G protein-coupled receptor (GPCR) crystallography where she determined the crystal structures of several important human GPCRs, including the k-opioid receptor, metabotropic glutamate receptor, and smoothened receptor. After completing her PhD, Dr. Wu joined Prof. Stuart L. Schreiber’s laboratory in the Broad Institute of Harvard and MIT (Cambridge, MA) for postdoctoral research, working on structure-based drug development (SBDD) targeting inflammatory bowel diseases. Dr. Wu currently serves as Director of Structural Biology at Pfizer (Groton, CT). Her team supports SBDD for small molecules, biologics, and vaccine antigen development within the company.
Seminars
- Leveraging machine learning–guided construct optimization to improve protein expression, stability, and cryo-EM suitability
- Accelerating structural determination of dynamic and difficult targets such as membrane proteins and large complexes
- Combining AI-assisted protein engineering with cryo-EM structural analysis to generate actionable SBDD insights
