Kasia Handing
Associate Director Tango Therapeutics
I am an Associate Director of Biochemistry at Tango Therapeutics with expertise in protein science and structural biology. At Tango, I focus on enabling early stage drug discovery through the development of biophysical and biochemical assays, as well as structural biology enablement, to support structure based drug discovery and guide compound development.
Seminars
Thursday 30th July 2026
Hit Finding & Assay Enablement for MGAT1, a Novel Glycosyl Transferase Involved in Cancer Cell Immune Evasion
9:00 am
- Identification of novel MGAT1 binders and inhibitors using two orthogonal discovery strategies: a UDPGlo™–based highthroughput enzymatic screen to identify functional inhibitors, and a DNAencoded library (DEL) screen to uncover compounds that bind MGAT1
- Mechanistic characterization of compound binding through the implementation of SPR competition assays, enabling direct interrogation of binding mode and target engagement
- Structural elucidation of ligand–MGAT1 interactions via highresolution crystal structures, revealing a welldefined binding site distinct from the active site and providing strong structural support for the proposed mechanism of action
