Nikhil Jain
Senior Scientist Insitro
Nikhil is an experienced structural biologist with over 15 years of expertise in cryo-electron microscopy, biophysics, and biochemistry, applying advanced structural approaches to support small molecule and DNA-encoded library–based drug discovery. He is a highly collaborative researcher with a strong publication and speaking record, known for leading interdisciplinary projects and working across global, cross-functional teams to advance scientific discovery
Seminars
Wednesday 29th July 2026
Aligning Construct Strategy, Stability & Biology for Modern Structure-Based Drug Design
9:30 am
- Designing construct strategies that maximize structural yield and biological fidelity
- Balancing speed and exploration when screening multiple protein variants in parallel
- Demonstrating why high expression yield alone is insufficient, and how prioritising functional competence and conformational relevance have prevented misleading ligand poses and downstream design errors
- Delving into expression, production, solubilisation, and stabilisation strategies to overcome heterogeneity and preserve biologically relevant conformations
