Steffen Bernard
Associate Director & Structural Biology Lead Vividion Therapeutics
I’m a structural biologist with 12 years of experience in X-ray crystallography. I have managed all aspects of projects from construct design, through structure determination and publication. I have experience determining structures of small molecule-protein complexes and multi-protein complexes at high resolution.
Seminars
Wednesday 29th July 2026
Panel Discussion: The Reality of Cryo-EM Access, Bottlenecks & Future Directions
12:00 pm
- Comparing access, cost, and timelines for large pharma versus biotechs, and when outsourcing or academic partnerships make more sense
- Addressing challenges around data volume, selection, and cloud storage
- How data processing, classification, and refinement workflows impact turnaround time and confidence in results
- Current constraints including size limits, flexibility, heterogeneity, and challenges with smaller molecules or weak interactions
- Emerging hardware, sample preparation strategies, and computational advances aimed at improving resolution, throughput, and applicability
Wednesday 29th July 2026
Building the Plane While Flying: Embedding Structural Biology in a Platform-Driven Discovery Model
1:45 pm
- Operating in a platform-driven discovery model where programs launch before full mechanistic understanding is established
- Using single-particle cryo-EM to resolve divergent mechanisms for distinct chemotypes binding the same pocket
- Identifying alternative binding sites on well-studied targets to enable differentiated pharmacology
