Vincent Stoll
Senior Director & Fellow in Research & Structural Biology Abbvie
Vincent S. Stoll is a Senior Research Fellow and Director of Structural Biology at AbbVie, a position they have held since 1997. With a strong passion for structure-based drug design and collaboration, they have previously served as Project Leader of X-ray Crystallography at Abbott & Associates and as Associate Director of Structural Biology at Abbott Laboratories. Vincent completed a postdoc in X-ray crystallography at the University of Toronto and holds a Master of Science and Ph.D. in Mechanistic Enzymology from Albert Einstein College of Medicine. Their academic journey began with a BA in Literature from Bard College.
Seminars
- Comparing access, cost, and timelines for large pharma versus biotechs, and when outsourcing or academic partnerships make more sense
- Addressing challenges around data volume, selection, and cloud storage
- How data processing, classification, and refinement workflows impact turnaround time and confidence in results
- Current constraints including size limits, flexibility, heterogeneity, and challenges with smaller molecules or weak interactions
- Emerging hardware, sample preparation strategies, and computational advances aimed at improving resolution, throughput, and applicability
As structural biology capabilities expand, drug discovery teams face a more complex challenge: not just generating structures, but deciding which structural and biophysical methods to deploy, when, and for what decision impact.
This interactive workshop moves beyond technique comparison to explore how X-ray crystallography, cryo-EM, cryo-ET, NMR, HDX-MS, native MS, SPR, ITC, and computational modelling integrate into coherent, decision-driving workflows.
Participants will examine how teams balance resolution, cost, speed, and interpretability
while ensuring structural outputs meaningfully inform molecule design, modality selection, and candidate advancement.
Workshop Highlights:
- Explore real-world case studies to learn how other teams integrate structural, biophysical, and computational data streams to manage conformational heterogeneity, validate binding hypotheses, and ensure experimental outputs are fit-for-purpose within discovery programs
- Exploring how X-ray, cryo-EM, NMR, HDX-MS, native MS, SPR/ITC and modelling outputs can be combined into a cohesive workflow that strengthens confidence in binding mode, mechanism, and optimization strategy
- Understanding the value proposition of different discovery teams and how they can best support each other to drive efficiency in discovery workflows
