Xinchao yu
Head of Structural Biology Gilead Sciences
Xinchao Yu brings more than 25 years of experience in cryo-EM and has established and led multiple high performance cryo EM facilities in the biopharmaceutical industry. He is a pioneer of high throughput cryo EM in industrial drug discovery, applying structural and functional analysis of protein complexes to drive the rational design of next generation therapeutics.
Seminars
Thursday 30th July 2026
Resolving an Allosteric Binding Pocket in the HSV H-P Complex to Inform Antiviral Drug Design
12:00 pm
- Optimizing Cryo-EM data acquisition and processing strategies to resolve ligand-bound states in conformationally heterogenous, multi-subunit viral complex
- Applying cryo-EM and complementary biophysical experiments to reveal ligand-stabilised allosteric binding sites that were absent in apo structures and not predictable from homology or co-folding models
- Recognizing limits of computational and biophysical methods, and utilizing mutational and omics data to validate binding sites
