Stabilizing Functional GPCR States Using ConfoBodies to Enable Structure-Guided Discovery

• Case study demonstrating how structural insights led to De Novo Nanobody discovery
• Addressing the challenge of isolating GPCRs from the membrane while preserving functional folding and conformational integrity for structural analysis
• Applying complementary structural and biophysical techniques to distinguish functionally relevant GPCR States from preparation-induced or non-productive conformations

Speakers:

Beatrice Li

Principal Scientist & Team Lead - Protein Science & Structural Biology

Confo Therapeutics