Advancing Structure-Based Drug Design: Tackling Challenging Targets and Complex Biologics
Time: 9:30 am
day: Day 1
Details:
- Leveraging structural biology techniques such as cryo-EM and hydrogen-deuterium exchange mass spectrometry to map antibody-drug conjugate (ADC) interactions with complex tumor-associated antigens
- Addressing the structural constraints and conformational dynamics that impact binding specificity, with insights into distinguishing closely related protein families such as CEACAMs
- Exploring how deep structural characterization informs the design of next-generation ADCs and other therapeutic modalities for precision targeting of difficult-to-drug proteins
