Deciphering Ion Channel Opening with Structural Interrogation from TimeResolved Cryo-EM to Small Molecule Modulation
Time: 8:30 am
day: Day 2
Details:
- Explore how time-resolved Cryo-EM enables visualization of ion channel conformational changes in real-time, shedding light on gating mechanisms and functional transitions
- Examine case studies on how ligand binding influences ion channel activity, stabilizing open or closed states and offering new opportunities for drug targeting
- Discuss strategies for working with challenging ion channel samples, optimizing data acquisition, and integrating multiple structural techniques to gain a comprehensive mechanistic understanding
