Powering SBDD with Industrial-Scale Cryo-EM Solutions
Time: 2:00 pm
day: Day 2
Details:
- GPR75: Revealing Activation Mechanisms in Orphan GPCRs: Shuimu Bio solved the world’s first high-resolution structure of GPR75, offering key insights into active-state stabilization and its implications for structure-based drug design (SBDD)
- CD73: From a Difficult Target to a Clinical Candidate: Through close collaboration with I-Mab Biopharma, successfully resolved the 3D structure of the CD73 dimerantibody complex, revealing the non-competitive mechanism of action
- Scalable Cryo-EM for Drug Discovery Acceleration: Shuimu’s industrial-scale Cryo-EM infrastructure and proprietary AI-assisted paltform enable high-throughput structural analysis of complex membrane proteins — reducing turnaround from months to weeks across discovery pipelines
