Alexey Rak

Company: Sanofi

Job title: Director & Head Of Global Bio Structure Biophysics Structural Biology & Biophysics

 

Seminars:

Structure-Guided Drug Design of MTA-Cooperative PRMT5 Inhibitors 8:30 am

  • Highlight rationale for targeting MTA-bound PRMT5 in MTAP-deleted cancers
  • Describe efforts informed by structure to convert SAM-cooperative PRMT5 inhibitors to MTA-cooperative PRMT5 inhibitors
  • Highlight role of structural biology during efforts to advance a different chemical series from a modestly potent HTS hit to the clinical-stage MTA-cooperative PRMT5 inhibitors TNG908 and TNG462

day: Day 1

Panel & Audience Discussion: Beyond the AI Hype – Overcoming the Barriers to Fully Maximizing AI in Drug Design 5:00 pm

This panel brings together experts to discuss the real challenges in adopting AI in drug design, moving beyond the hype to practical solutions for overcoming barriers related to data quality, integration, and model reliability.

  • What are the current limitations and challenges in leveraging AI within the context of drug design and structural biology?
  • How can the scientific community ensure that AI models are properly validated, integrated with experimental data, and implemented in real-world workflows?
  • What advancements are needed in AI, data management, and experimental techniques to unlock its full potential for drug development?

day: Day 1

Alexey Rak