Hetal Marble

Company: Immuto Scientific

Job title: Head of Commercial

 

Seminars:

Structure without Compromise: Empirical Epitope Mapping for High- Throughput Hit-to-Lead and Optimization 1:30 pm

• The best antibodies are those that exhibit specificity to disease or targets, that limit liabilities for production and therapeutic delivery, and that demonstrate the best function – but these are difficult to predict when relying on the typical antibody characterization approaches
• By leveraging high-throughput, high-resolution structure determination and combining it with more conventional bioanalytical and functional assessments, we systematically selected for the antibodies exhibiting the most desirable attributes against several mechanistic targets
• We demonstrate how structural insights can be gleaned from very difficult targets, including on membrane-stabilized GPCRs, and how dynamics in addition to binding sites are critical to function and prediction

day: Day 1