Jason Yano
Director & Head of Structural Biology Revolution Medicines
Innovative scientist with a passion for utilizing skills as a structural biologist to drive small molecule design. Nearly 20 years of industry experience working on more than 30 small molecule campaigns against broad classes of proteins such as RAS, GPCRs, ion channels, kinases, proteases, NHRs, P450s and other assorted enzymes. Currently building up the Structural Biology and Protein Chemistry capabilities at Revolution Medicines.
Seminars
Thursday 30th July 2026
Reframing Structure-Based Drug Design for Induced Proximity Modalities in Multi-Protein Systems
11:30 am
- Designing constructs, stabilization strategies, and binding partners to bias multi-protein assemblies toward structurally tractable states without distorting biology
- Determining when cryo-EM, crystallography, HDX-MS, or native MS are best suited to resolve induced proximity complexes with partial or dynamic occupancy
- Evaluating where co-folding, docking and modelling of multi-protein assemblies have aligned with function
- Strategies for managing scale and throughput when programs demand repeated structural readouts
